- Circadian and Visual Neuroscience (Peirson) Research Group
Stuart Peirson is a Senior Research Scientist in the Nuffield Laboratory of Ophthalmology. After completing his PhD in Neuroscience at the Institute of Ophthalmology UCL on photopigments and circadian biology he moved to Imperial College to work as a BBSRC postdoctoral Research Associate. During this time Dr Peirson also acted as technical supervisor for the quantitative real-time PCR (qPCR) facility at Charing Cross Hospital. Working as a Wellcome Trust Research Associate, Dr Peirson contributed to the identification of the melanopsin pRGC system in humans as well as the characterisation of melanopsin signalling pathways. Dr Peirson was appointed as a Lecturer at Imperial College in 2005 before moving to the University of Oxford in 2006. His work has continued to focus on circadian photobiology, characterisation of genes involved in circadian entrainment and identification of novel targets for the regulation of circadian rhythms and sleep. Through collaborations with clinical colleagues in the Oxford Eye Hospital he has also been involved in evaluating the impact of ocular disease on sleep and circadian rhythms.
Senior Research Scientist
The vertebrate retina contains photoreceptors that mediate the dual tasks of image formation and irradiance (brightness) detection. My research focuses on how the light environment regulates physiology and behaviour. These irradiance detection tasks include the regulation of the circadian clock, locomotor activity, sleep/wake timing, pupil constriction, pineal melatonin synthesis and heart rate. The central aims of this work are to understand how light information is transmitted from photoreceptor to brain and to identify the exent to which physiology and behaviour is regulated by light. This work relies upon the a range of molecular techniques such as the measurement of gene expression (using qPCR and microarrays) and gene silencing, in addition to an array of behavioural techniques including circadian behavioural monitoring, pupillometry and sleep scoring. Photobiology, biostatistics and bioinformatics critically underpin this work.
Sources of Funding
Measuring and using light in the melanopsin age.
Lucas RJ. et al, (2014), Trends Neurosci, 37, 1 - 9
Measuring and using light in the melanopsin age
Lucas RJ. et al, (2014), Trends in Neurosciences, 37, 1 - 9
Irradiance encoding in the suprachiasmatic nuclei by rod and cone photoreceptors.
van Diepen HC. et al, (2013), Faseb J, 27, 4204 - 4212
Sleep and circadian rhythm disruption in neuropsychiatric illness
Jagannath A. et al, (2013), Current Opinion in Neurobiology, 23, 888 - 894
Black intraocular lenses: Near infra-red light transmission may risk treatment failure
Yusuf IH. et al, (2013), British Journal of Ophthalmology, 97, 1353 - 1354