Sumathi Sekaran BSc PhD
Research Themes
Divisional Themes
- Developmental and Stem Cell Biology
- Neuroscience
- Cell and Molecular Biology
- Ion Channels and Transporters
- Imaging
NLO Themes
Group Members
- Christiana Katti, Postdoctoral Reseacher
Publications from S.Sekaran
- Sekaran Sumathi, Lall Gurprit S, Ralphs Katherine L, Wolstenholme Adrian J, Lucas Robert J, Foster Russell G, and Hankins Mark W (2007) 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. J Neurosci, 27(15):3981-6.
- Lupi Daniela, Sekaran Sumathi, Jones Sarah L, Hankins Mark W, and Foster Russell G (2006) Light-evoked FOS induction within the suprachiasmatic nuclei (SCN) of melanopsin knockout (Opn4-/-) mice: a developmental study. Chronobiol Int, 23(1-2):167-79.
- Sekaran S, Lupi D, Jones S L, Sheely C J, Hattar S, Yau K-W, Lucas R J, Foster R G, and Hankins M W (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol, 15(12):1099-107.
- Barnard Alun R, Appleford Joanne M, Sekaran Sumathi, Chinthapalli Krishna, Jenkins Aaron, Seeliger Matheas, Biel Martin, Humphries Peter, Douglas Ron H, Wenzel Andreas, Foster Russell G, Hankins Mark W, and Lucas Robert J (2004) Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit. Vis Neurosci, 21(5):675-83.
- Sekaran Sumathi, Foster Russell G, Lucas Robert J, and Hankins Mark W (2003) Calcium imaging reveals a network of intrinsically light-sensitive inner-retinal neurons. Curr Biol, 13(15):1290-8.
| Contact address | Levels 5 & 6 West Wing, The John Radcliffe Hospital, Headley Way, Oxford, Oxfordshire, OX3 9DU, United Kingdom |
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Novel Inner Retinal Photoreceptor Cells. Using calcium imaging, intrinsice light responses of photosensitive retinal ganglion cells are revealed.
Over the past 200 years the vertebrate retina has been characterized extensively. However, the recent discovery of a novel photoreceptor cell in the inner retina has revolutionised retinal neuroscience research. These ‘photosensitive retinal ganglion cells’ primarily drive non-visual responses to light including circadian photoentrainment and the pupil light reflex. My research has focused on the physiological characterisation of photosensitive retinal ganglion cells, the developmental emergence of inner retinal photosensitivity and investigations into how these cells integrate within the retinal neuronal network.
Biography
Dr Sekaran completed her BSc and PhD at Imperial College London. She was appointed to a Lectureship in Visual Neuroscience at Imperial College London in 2005 and was subsequently appointed as a Senior Research Scientist at the University of Oxford in 2006.
