Robert MacLaren

• Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina Plos One 8 (2013)
• Reply: Cataract surgery and microphthalmic eyes. J Cataract Refract Surg 39 (2013)
• Gene therapy for retinal disease Transl Res 161 (2013)
• Variations in opsin coding sequences cause X-linked cone dysfunction syndrome with myopia and dichromacy Invest Ophthalmol Vis Sci 54 (2013)
• Non-Image-Forming Light Driven Functions Are Preserved in a Mouse Model of Autosomal Dominant Optic Atrophy Plos One 8 (2013)
• A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 54 (2013)
• Clinical applications of retinal gene therapy. Prog Retin Eye Res 32 (2013)
• Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos J Cataract Refract Surg 39 (2013)
• X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene Vision Res 80 (2013)
• Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation Proc Natl Acad Sci U S A 110 (2013)
• Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. Hum Mol Genet (2013)
• Macular Hole Surgery in Patients with End-stage Choroideremia Ophthalmology (2013)
• Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases. Curr Gene Ther 13 (2013)
• Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration Invest Ophthalmol Vis Sci 53 (2012)
• Non-viral retinal gene therapy: A review Clin Experiment Ophthalmol 40 (2012)
• Pilot randomised controlled trial of face-down positioning following macular hole surgery Eye (Lond) 26 (2012)
• Gene therapy for retinal dystrophies Ophthalmologe 109 (2012)
• Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR). Invest Ophthalmol Vis Sci 53 (2012)
• Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration Invest Ophthalmol Vis Sci 53 (2012)
• Focus on molecules: neural retina leucine zipper (NRL). Exp Eye Res 104 (2012)
• Choroidal new vessels in type 1 myotonic dystrophy-related macular dystrophy respond to anti-VEGF therapy. Eye (Lond) 26 (2012)
• Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival Cell Transplant 21 (2012)
• Leber congenital amaurosis associated with AIPL1: Challenges in ascribing disease causation, clinical findings, and implications for gene therapy Plos One 7 (2012)
• Non-viral retinal gene therapy: A review Clinical and Experimental Ophthalmology 40 (2012)
• Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling Plos One 7 (2012)
• Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro Exp Eye Res 97 (2012)
• The p53 Codon 72 Polymorphism (rs1042522) is Associated with Proliferative Vitreoretinopathy: The Retina 4 Project. Ophthalmology (2012)
• Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of loci associated with human dominant retinal dystrophy Invest Ophthalmol Vis Sci 52 (2011)
• Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy Exp Eye Res 93 (2011)
• AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells. Invest Ophthalmol Vis Sci 52 (2011)
• Combined phacoemulsification and removal of gas following macular hole surgery J Cataract Refract Surg 37 (2011)
• Sources of retinal pigment epithelium (RPE) for replacement therapy Br J Ophthalmol 95 (2011)
• Assessment of cone survival in response to CNTF, GDNF, and VEGF 165b in a novel ex vivo model of end-stage retinitis pigmentosa Invest Ophthalmol Vis Sci 52 (2011)
• Responsiveness of choroidal neovascular membranes in patients with R345W mutation in fibulin 3 (Doyne honeycomb retinal dystrophy) to anti-vascular endothelial growth factor therapy Arch Ophthalmol 129 (2011)
• Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions Bmc Biotechnol 11 (2011)
• Stem cells as a therapeutic tool for the blind: Biology and future prospects Proceedings of the Royal Society B: Biological Sciences 278 (2011)
• Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia Invest Ophthalmol Vis Sci 51 (2010)
• Induced pluripotent stem cell therapies for retinal disease Curr Opin Neurol 23 (2010)
• Arterial occlusion after scleral buckling Br J Ophthalmol 94 (2010)
• Macular Function Assessed by Microperimetry in Patients with Enhanced S-Cone Syndrome Ophthalmology 117 (2010)
• Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation Stem Cells 28 (2010)
• Arterial occlusion after scleral buckling British Journal of Ophthalmology 94 (2010)
• Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina Cell Transplant 19 (2010)
• Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration Clin Experiment Ophthalmol 37 (2009)
• Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice J Gene Med 11 (2009)
• Scleral punch method with topical mitomycin c for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome Graefes Arch Clin Exp Ophthalmol 247 (2009)
• ADVIRC is caused by distinct mutations in BEST1 that alter pre-mRNA splicing J Med Genet 46 (2009)
• An analysis of retinal gene therapy clinical trials Curr Opin Mol Ther 11 (2009)
• The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages Invest Ophthalmol Vis Sci 50 (2009)
• Cell transplantation strategies for retinal repair Prog Brain Res 175 (2009)
• Development of a murine model of age-related macular degeneration by overexpression of complement component 3 in the RPE of MCP-1(-/-) and wild-type mice Conference (2008)
• Overexpression of developmentally regulated neurotrophins in the adult mouse retina to facilitate integration of transplanted photoreceptor precursor cells Conference (2008)
• Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors Exp Eye Res 86 (2008)
• Isolation and characterisation of neural progenitor cells from the adult Chx10orJ/orJ central neural retina Mol Cell Neurosci 38 (2008)
• Stickler Syndrome Ophthalmology 115 (2008)
• Implantation of the Black Diaphragm Intraocular Lens in Congenital and Traumatic Aniridia Ophthalmology 115 (2008)
• Autologous Transplantation of the Retinal Pigment Epithelium and Choroid in the Treatment of Neovascular Age-Related Macular Degeneration Ophthalmology 114 (2007)
• Biometry and Formula Accuracy With Intraocular Lenses Used for Cataract Surgery in Extreme Hyperopia Am J Ophthalmol 143 (2007)
• Stem cell therapy and the retina Eye (Lond) 21 (2007)
• Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye Stem Cells 25 (2007)
• Neuroprotective gene therapy for the treatment of inherited retinal degeneration Curr Gene Ther 7 (2007)
• Effective gene therapy with nonintegrating lentiviral vectors Nat Med 12 (2006)
• Variable phenotypes in patients diagnosed with idiopathic multifocal choroiditis. Clin Experiment Ophthalmol 34 (2006)
• Submacular surgery - Reply Ophthalmology 113 (2006)
• EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV Gene Ther 13 (2006)
• Uveitic glaucoma and Rosai-Dorfman disease (sinus histiocytosis) Ocul Immunol Inflamm 14 (2006)
• In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration Mol Ther 14 (2006)
• CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion Exp Eye Res 83 (2006)
• Variable phenotypes in patients diagnosed with idiopathic multifocal choroiditis Conference (2006)
• Retinal repair by transplantation of photoreceptor precursors Nature 444 (2006)
• Delayed atrophy of the retinal pigment epithelium after submacular surgery Eur J Ophthalmol 15 (2005)
• Biometry accuracy using zero- and negative-powered intraocular lenses J Cataract Refract Surg 31 (2005)
• Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration Ophthalmology 112 (2005)
• Intraretinal regeneration of axotomised retinal ganglion cells after AAV mediated CNTF delivery Conference (2005)
• Immature neural retinal cells integrate and differentiate into photoreceptors when transplanted into the mouse subreitnal space at post-natal day 1 Conference (2005)
• Risks of gene therapy should be weighed against lack of alternatives for many disease [6] Bmj 330 (2005)
• Visual outcome in patients with idiopathic multifocal choroiditis Conference (2004)
• School exam results matter in medical job applications [5] Bmj 328 (2004)
• Benign idiopathic haemorrhagic retinopathy [9] Eye (Lond) 16 (2002)
• Spontaneous foreign body extrusion following perforating eye injury. J R Army Med Corps 148 (2002)
• Fluorescein angiography in altitude retinopathy Br J Ophthalmol 84 (2000)
• Re-establishment of visual circuitry after optic nerve regeneration. Eye (Lond) 13 ( Pt 3a) (1999)
• A glial palisade delineates the ipsilateral optic projection in Monodelphis. Vis Neurosci 15 (1998)
• Intracranial plasmacytoma masquerading as Gradenigo's syndrome. Br J Ophthalmol 82 (1998)
• Regeneration and transplantation of the optic nerve: developing a clinical strategy. Br J Ophthalmol 82 (1998)
• Chiasmatic specificity in the regenerating mammalian optic nerve Exp Neurol 147 (1997)
• Regeneration in the developing optic nerve: Correlating observations in the opossum to other mammalian systems Prog Neurobiol 53 (1997)
• Development and role of retinal glia in regeneration of ganglion cells following retinal injury. Br J Ophthalmol 80 (1996)
• Expression of myelin proteins in the opossum optic nerve: late appearance of inhibitors implicates an earlier non-myelin factor in preventing ganglion cell regeneration. J Comp Neurol 372 (1996)
• Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J Neurosci 16 (1996)

Key publications

• Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation Proc Natl Acad Sci U S A 110 (2013)
• Assessment of 180° rotation of the choroid as a novel surgical treatment for age-related macular degeneration Invest Ophthalmol Vis Sci 53 (2012)
• Autologous Transplantation of the Retinal Pigment Epithelium and Choroid in the Treatment of Neovascular Age-Related Macular Degeneration Ophthalmology 114 (2007)
• Retinal repair by transplantation of photoreceptor precursors Nature 444 (2006)