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Publications from N.Osborne

  • Neville N Osborne (2009): Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned. - Acta Ophthalmol, 87(4):450-4.
  • Belmira Lara da Silveira Andrade da Costa, Kui Dong Kang, Kay D Rittenhouse and Neville N Osborne (2009): The localization of PGE2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost. - Neurochem Int, 55(4):199-207.
  • Neville N Osborne, Guang-Yu Li, Dan Ji, Belmira L Andrade da Costa, Rebecca J Fawcett, Kui Dong Kang and Kay D Rittenhouse (2009): Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia. - Invest Ophthalmol Vis Sci, 50(7):3238-48.
  • Glyn Chidlow, John P M Wood, Jim Manavis, Neville N Osborne and Robert J Casson (2008): Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries. - Invest Ophthalmol Vis Sci, 49(2):762-71.
  • Dan Ji, Guang-Yu Li and Neville N Osborne (2008): Nicotinamide attenuates retinal ischemia and light insults to neurones. - Neurochem Int, 52(4-5):786-98.
  • N N Osborne (1985): Cholecystokinin in the retina of vertebrates. - Ann N Y Acad Sci, 448:157-66.
  • H U Schroder, V Neuhoff, E Priggemeier and N N Osborne (1979): The influx of tryptamine into snail (Helix pomatia) ganglia: comparison with 5-hydroxytryptamine. - Malacologia, 18(1-2):517-25.
  • N N Osborne (1981): Binding of [3H]serotonin to membranes of the bovine retina. - Exp Eye Res, 33(4):371-80.
  • N N Osborne and V Neuhoff (1983): Characterization and isolation of mammalian retinal neurons. - Biochem Soc Trans, 11(6):682-4.
  • N N Osborne and G Richardson (1980): Specificity of serotonin uptake by bovine retina: comparison with tryptamine. - Exp Eye Res, 31(1):31-9.
  • N N Osborne and H Ghazi (1988): Does noradrenaline behave as a neurotransmitter or hormone in the mammalian retina? - Neurosci Res Suppl, 8:S197-210.
  • N N Osborne (1992): Carbachol-induced stimulation of inositol phosphates, arachidonic acid and prostaglandin F2 alpha in rabbit retina. - Adv Exp Med Biol, 318:259-65.
  • V W Pentreath and N N Osborne (1975): Effects of 5,7-dihydroxytryptamine on transmission at serotoninergic synapses. - J Pharm Pharmacol, 27(4):293-4.
  • N N Osborne, P B Guthrie and V Neuhoff (1976): Tyrosine hydroxylase in snail (Helix pomatia) nervous tissue. - Biochem Pharmacol, 25(8):925-31.
  • N N Osborne and N Koppang (1985): Tyrosine-hydroxylase immunoreactivity in retinas from a canine model for Batten-Stengel disease. - Naturwissenschaften, 72(1):44-6.
  • W L Stahl, V Neuhoff and N N Osborne (1977): Role of sodium in uptake of 5-hydroxytryptamine by Helix ganglia. - Comp Biochem Physiol C, 56(1):13-8.
  • N N Osborne (1979): Some properties and the axonal transport of choline acetyltransferase in nervous tissue of the snail Helix pomatia. - Biochem Pharmacol, 28(7):1257-9.
  • N N Osborne, L Hiripi and V Neuhoff (1975): The in vitro uptake of biogenic amines by snail (Heliz pomatia) nervous tissue. - Biochem Pharmacol, 24(23):2141-8.
  • N N Osborne (1972): Serotonin, free amino-acids, and related substances occurring in the blood and nervous tissue of Helix aspersa (gastropoda mollusca). - Comp Gen Pharmacol, 3(10):171-7.
  • H A Robertson and N N Osborne (1979): Putative neurotransmitters in the annelid central nervous system: presence of 5-hydroxytryptamine and octopamine-stimulated adenylate cyclases. - Comp Biochem Physiol C, 64(1):7-14.
  • N N Osborne (1973): Proceedings: Application of the dansyl procedure to study the metabolism and accumulation of 5-hydroxytryptamine in characterized neurones of Helix pomatia. - Br J Pharmacol, 49(1):170P-171P.
  • N N Osborne, G Chidlow, J P Wood, K G Schmidt, R Casson and J Melena (2001): Expectations in the treatment of retinal diseases: neuroprotection. - Curr Eye Res, 22(5):321-32.
  • N N Osborne and G A Cottrell (1974): Proceedings: Effect of 5,7-dihydroxytryptamine on the metabolism and accumulation of 5-hydroxytryptamine in the snail CNS. - Br J Pharmacol, 52(1):152P-153P.
  • N N Osborne, T V Waehneldt and V Neuhoff (1973): The effect of LSD-25 on amines, amino-acids, and proteins in the snail (Helix pomatia) brain. - Comp Gen Pharmacol, 4(15):259-66.
  • N N Osborne and V Neuhoff (1974): In vitro experiments on the metabolism, accumulation and release of 5-HT in the nervous system of the snail Helix pomatia. - J Neurochem, 22(3):363-71.
  • N N Osborne, D A Nicholas, G J Dockray and A C Cuello (1982): Cholecystokinin and substance P immunoreactivity in retinas of rats, frogs, lizards and chicks. - Exp Eye Res, 34(4):639-49.
  • B E Leonard, V Neuhoff and N N Osborne (1973): Proceedings: Use of dansyl chloride to detect amino acids and 5-hydroxytryptamine in small quantities of tissue. - Br J Pharmacol, 49(1):178P-179P.
  • N N Osborne and V Neuhoff (1972): Use of dansyl chloride and microchromatography to detect and study the metabolism of suspected transmitter substances and amino acids in single neurons. - Biochem J, 128(3):82P-83P.
  • N N Osborne, J P Wood, G Chidlow, J H Bae, J Melena and M S Nash (1999): Ganglion cell death in glaucoma: what do we really know? - Br J Ophthalmol, 83(8):980-6.
  • J P Wood, R McCord, N Groome and N N Osborne (1994): Phorbol esters, kainate and ischaemia influence protein kinase C alpha, delta and zeta in the rabbit retina, in vitro. - Biochem Soc Trans, 22(3):289S.
  • N N Osborne, J Melena, G Chidlow and J P Wood (2001): A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma. - Br J Ophthalmol, 85(10):1252-9.
  • N N Osborne, V Neuhoff and B E Leonard (1974): The effect of fenfluramine, 2,5-dimethoxy-4-methyl amphetamine (DOM) and D-amphetamine on the concentration of serotonin and some free amino acids in the suboesophageal ganglia of Helix pomatia. - Z Naturforsch C, 29(3):189-90.
  • N N Osborne, N Cutcliffe and A Peard (1986): Trace amines (ethylamine, octopamine, and tryptamine) stimulate inositol phospholipid hydrolysis in rat cerebral cortex slices. - Neurochem Res, 11(11):1525-31.
  • N N Osborne and S Patel (1984): Localisation of histamine-immunoreactivity in specific neurones of the gastropod CNS including a cell which has been identified as histaminergic. - Histochemistry, 81(2):207-8.
  • N N Osborne, D A Nicholas, A C Cuello and G J Dockray (1981): Localization of cholecystokinin immunoreactivity in amacrine cells of the retina. - Neurosci Lett, 26(1):31-5.
  • G E Fagc, V Neuhoff, K H Sontag and N N Osborne (1978): Myelin composition in the central nervous system of mutant Han-Wistar rats. - Neurosci Lett, 9(2-3):201-5.
  • N N Osborne and D W Beaton (1985): Occurrence of serotonin-accumulating neurones in cultures of retina from the human foetus. - Neurosci Lett, 55(2):229-32.
  • N N Osborne (1980): Benzodiazepine binding to bovine retina. - Neurosci Lett, 16(2):167-70.
  • N N Osborne, E F Coelle, V Neuhoff and K H Sontag (1977): Mutant spastic Han-Wistar rats: Biochemical abnormalities in their striata. - Neurosci Lett, 6(2-3):251-4.
  • N N Osborne, D W Beaton, A Vigny and V Neuhoff (1984): Localization of tyrosine-hydroxylase immunoreactive cells in rabbit retinal cultures. - Neurosci Lett, 50(1-3):117-20.
  • N N Osborne, A B Tobin and H Ghazi (1988): Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay. - Neurochem Res, 13(3):177-91.
  • N N Osborne and T Nesselhut (1983): Adrenaline: occurrence in the bovine retina. - Neurosci Lett, 39(1):33-6.
  • N N Osborne, A C Cuello and G J Dockray (1982): Substance P and cholecystokinin-like peptides in Helix neurons and cholecystokinin and serotonin in a giant neuron. - Science, 216(4544):409-11.
  • E F Coelle, N N Osborne, V Neuhoff and K H Sontag (1979): [The influence of benzoctamine on dopamine and norepinephrine contents in substantia nigra and on the muscle stretch reflex of the cat (author's transl)]. - Arzneimittelforschung, 29(10):1556-60.
  • S Wolfarth, E F Coelle, N N Osborne and K H Sontag (1977): Evidence for a neurotoxic effect of ascorbic acid after an intranigral injection in the cat. - Neurosci Lett, 6(2-3):183-6.
  • N N Osborne (1994): Serotonin and melatonin in the iris/ciliary processes and their involvement in intraocular pressure. - Acta Neurobiol Exp (Wars), 54 Suppl:57-64.
  • N N Osborne, R Safa and M S Nash (1999): Photoreceptors are preferentially affected in the rat retina following permanent occlusion of the carotid arteries. - Vision Res, 39(24):3995-4002.
  • K H Sontag, P Wand, M Schwarz, W Wesemann and N N Osborne (1982): [The Effect of memantine on spinal alpha-motoneurons and on the content of dopamine, noradrenaline and serotonin in the striatum and lumbar spinal cord]. - Arzneimittelforschung, 32(10):1236-40.
  • E Vecino, E Caminos, M Ugarte, D Martin-Zanca and N N Osborne (1998): Immunohistochemical distribution of neurotrophins and their receptors in the rat retina and the effects of ischemia and reperfusion. - Gen Pharmacol, 30(3):305-14.
  • T Nesselhut and N N Osborne (1982): Is noradrenaline a major catecholamine in the bovine retina? - Neurosci Lett, 28(1):41-5.
  • N N Osborne, D W Beaton, P J Boyd and R J Walker (1986): Substance P-like immunoreactivity in the retina and optic lobe of the squid. - Neurosci Lett, 70(1):65-8.
  • A Reichenbach, M Kasper, J Schnitzer, N N Osborne and S Pritz-Hohmeier (1994): A set of early-born neurons is distinctly labeled by several defined antibodies in the adult rabbit retina. - J Hirnforsch, 35(3):391-5.
  • N N Osborne, F Block and K H Sontag (1991): Reduction of ocular blood flow results in glial fibrillary acidic protein (GFAP) expression in rat retinal Muller cells. - Vis Neurosci, 7(6):637-9.
  • N N Osborne and G Chidlow (1996): Do beta-adrenoceptors and serotonin 5-HT1A receptors have similar functions in the control of intraocular pressure in the rabbit? - Ophthalmologica, 210(5):308-14.
  • N N Osborne (1980): Binding of [3H]-muscimol, a potent gamma-aminobutyric acid receptor agonist, to membranes of the bovine retina. - Br J Pharmacol, 71(1):259-64.
  • N N Osborne and N L Barnett (1992): Endothelin-1 stimulates phosphatidylinositol hydrolysis in the iris/ciliary complex and is a potent constrictor of the sphincter muscle. - Exp Eye Res, 54(2):285-90.
  • R A Leslie and N N Osborne (1984): Amines and other transmitter-like compounds in the bovine area postrema. - Brain Res Bull, 13(3):357-62.
  • N Klemm, D R Nassel and N N Osborne (1985): Dopamine-beta-hydroxylase-like immunoreactive neurons in two insect species, Calliphora erythrocephala and Periplaneta americana. - Histochemistry, 83(2):159-64.
  • N N Osborne and D W Beaton (1986): The occurrence of gamma-aminobutyric acid (GABA)-containing cells in cultures of retinas from the human fetus. - Cell Mol Neurobiol, 6(1):87-93.
  • K-G Schmidt, L E Pillunat and N N Osborne (2004): [Ischemia and hypoxia. An attempt to explain the different rates of retinal ganglion cell death in glaucoma]. - Ophthalmologe, 101(11):1071-5.
  • J P Wood and N N Osborne (1998): Expression of protein kinase C isoenzymes in cultured hooded rat retinal pigmented epithelial cells: comparison with dystrophic Royal College of Surgeons rat. - Curr Eye Res, 17(7):757-60.
  • N N Osborne and V H Perry (1985): Effect of neonatal optic nerve transection on some classes of amacrine cells in the rat retina. - Brain Res, 343(2):230-5.
  • E Vecino, M Ugarte, M S Nash and N N Osborne (1999): NMDA induces BDNF expression in the albino rat retina in vivo. - Neuroreport, 10(5):1103-6.
  • N N Osborne, G Pergande, F Block and M Schwarz (1994): Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina. - Brain Res, 667(2):291-4.
  • M S Nash, J P Wood, J Melena and N N Osborne (2000): Flupirtine ameliorates ischaemic-like death of rat retinal ganglion cells by preventing calcium influx. - Brain Res, 856(1-2):236-9.
  • Simone Beretta, John P M Wood, Barry Derham, Gessica Sala, Lucio Tremolizzo, Carlo Ferrarese and Neville N Osborne (2006): Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON). - Neurobiol Dis, 24(2):308-17.
  • N L Barnett and N N Osborne (1995): Redistribution of GABA immunoreactivity following central retinal artery occlusion. - Brain Res, 677(2):337-40.
  • N N Osborne (1984): Substance P in the bovine retina: localization, identification, release, uptake and receptor analysis. - J Physiol, 349:83-93.
  • Glyn Chidlow, Paul S Hiscott and Neville N Osborne (2004): Expression of serotonin receptor mRNAs in human ciliary body: a polymerase chain reaction study. - Graefes Arch Clin Exp Ophthalmol, 242(3):259-64.
  • John P M Wood and Neville N Osborne (2003): Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells. - Neurochem Res, 28(10):1525-33.
  • N N Osborne (1991): Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina. - Brain Res, 553(1):84-8.
  • N N Osborne, T Nesselhut, D A Nicholas, S Patel and A C Cuello (1982): Serotonin-containing neurones in vertebrate retinas. - J Neurochem, 39(6):1519-28.
  • N L Barnett and N N Osborne (1993): The effect of serotonin on the rabbit isolated iris sphincter muscle. - Curr Eye Res, 12(7):665-73.
  • J Melena, J P Wood and N N Osborne (1999): Betaxolol, a beta1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels. - Eur J Pharmacol, 378(3):317-22.
  • N N Osborne (1973): Tryptophan metabolism in characterized neurones of Helix. - Br J Pharmacol, 48(3):546-9.
  • N N Osborne and D W Beaton (1986): Studies on serotonin-accumulating cells in rabbit retinal cultures. - Brain Res, 362(2):287-98.
  • N N Osborne and S Patel (1984): Postnatal development of serotonin-accumulating neurones in the rabbit retina and an immunohistochemical analysis of the uptake and release of serotonin. - Exp Eye Res, 38(6):611-20.
  • P J Boyd, N N Osborne and R J Walker (1986): Localization of a substance P-like material in the central and peripheral nervous system of the snail Helix aspersa. - Histochemistry, 84(1):97-103.
  • N N Osborne and N L Barnett (1992): An intraocular injection of kainate induces expression of c-fos-like protein and activation of protein kinase C (alpha) in specific rabbit retinal neurones. - Brain Res Mol Brain Res, 15(1-2):108-12.
  • G Chidlow and N N Osborne (1997): Antagonism of muscarinic receptors in the rabbit iris-ciliary body by 8-OH-DPAT and other 5-HT1A receptor agonists. - J Neural Transm, 104(10):1015-25.
  • N N Osborne (1982): Binding of (-)[3H]noradrenaline to bovine membrane of the retina. Evidence for the existence of alpha 2-receptors. - Vision Res, 22(11):1401-7.
  • N N Osborne, S Patel and A Vigny (1984): Dopaminergic neurones in various retinas and the postnatal development of tyrosine-hydroxylase immunoreactivity in the rabbit retina. - Histochemistry, 80(4):389-93.
  • M Ugarte and N N Osborne (1998): The localization of endogenous zinc and the in vitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina. - Gen Pharmacol, 30(3):297-303.
  • N N Osborne (1990): Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina. - Neurochem Res, 15(5):523-8.
  • N Cutcliffe and N N Osborne (1987): Serotonergic and cholinergic stimulation of inositol phosphate formation in the rabbit retina. Evidence for the presence of serotonin and muscarinic receptors. - Brain Res, 421(1-2):95-104.
  • C J Layton, J P M Wood, G Chidlow and N N Osborne (2005): Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner. - J Neurochem, 92(3):487-93.
  • R Beale and N N Osborne (1983): Selective uptake of tritiated glycine, GABA and D-aspartate by retinal cells in culture: a study using autoradiography and simultaneous immunofluorescence. - Brain Res, 283(2-3):107-20.
  • A B Tobin and N N Osborne (1989): Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. - J Neurochem, 53(3):686-91.
  • N N Osborne, N L Barnett and A J Herrera (1993): NADPH diaphorase localization and nitric oxide synthetase activity in the retina and anterior uvea of the rabbit eye. - Brain Res, 610(2):194-8.
  • N N Osborne and V W Pentreath (1976): Effects of 5,7-dihydroxytryptamine on an identified 5-hydroxytryptamine-containing neurone in the central nervous sytem of the snail Helix pomatia. - Br J Pharmacol, 56(1):29-38.
  • G J Dockray, C Vaillant, R G Williams, R J Gayton and N N Osborne (1981): Vertebrate brain-gut peptides related to FMRFamide and Met-enkephalin Arg6Phe7. - Peptides, 2 Suppl 2:25-30.
  • N N Osborne and V Neuhoff (1976): Activation of snail (Helix pomatia) nervous tissue tyrosine monooxygenase by calcium in vitro. - Hoppe Seylers Z Physiol Chem, 357(9):1271-5.
  • Natalie D Bull, John P Wood, Neville N Osborne and Nigel L Barnett (2007): Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. - Curr Eye Res, 32(2):123-31.
  • N N Osborne and G Chidlow (1994): The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eye. - Exp Eye Res, 59(1):3-9.
  • Neville N Osborne, Robert J Casson, John P M Wood, Glyn Chidlow, Mark Graham and Jose Melena (2004): Retinal ischemia: mechanisms of damage and potential therapeutic strategies. - Prog Retin Eye Res, 23(1):91-147.
  • N N Osborne, F FitzGibbon and G Schwartz (1991): Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured human retinal pigment epithelium cells. - Vision Res, 31(7-8):1119-27.
  • N N Osborne, J Wood and N Groome (1994): The occurrence of three calcium-independent protein kinase C subspecies (delta, epsilon and zeta) in retina of different species. - Brain Res, 637(1-2):156-62.
  • C Cazevieille, R Safa and N N Osborne (1997): Melatonin protects primary cultures of rat cortical neurones from NMDA excitotoxicity and hypoxia/reoxygenation. - Brain Res, 768(1-2):120-4.
  • R Safa and N N Osborne (2000): Retinas from albino rats are more susceptible to ischaemic damage than age-matched pigmented animals. - Brain Res, 862(1-2):36-42.
  • N N Osborne, G Chidlow, M S Nash and J P Wood (1999): The potential of neuroprotection in glaucoma treatment. - Curr Opin Ophthalmol, 10(2):82-92.
  • Robert J Casson, Glyn Chidlow, James P M Wood and Neville N Osborne (2004): The effect of hyperglycemia on experimental retinal ischemia. - Arch Ophthalmol, 122(3):361-6.
  • J Melena, G Chidlow and N N Osborne (2000): Blockade of voltage-sensitive Na(+) channels by the 5-HT(1A) receptor agonist 8-OH-DPAT: possible significance for neuroprotection. - Eur J Pharmacol, 406(3):319-24.
  • N L Barnett and N N Osborne (1995): Prolonged bilateral carotid artery occlusion induces electrophysiological and immunohistochemical changes to the rat retina without causing histological damage. - Exp Eye Res, 61(1):83-90.
  • G Chidlow, K-G Schmidt, J P M Wood, J Melena and N N Osborne (2002): Alpha-lipoic acid protects the retina against ischemia-reperfusion. - Neuropharmacology, 43(6):1015-25.
  • N N Osborne and D W Beaton (1986): Direct histochemical localisation of 5,7-dihydroxytryptamine and the uptake of serotonin by a subpopulation of GABA neurones in the rabbit retina. - Brain Res, 382(1):158-62.
  • C Cazevieille and N N Osborne (1997): Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not -- melatonin counteracts the effects of ischaemia and kainate. - Brain Res, 755(1):91-100.
  • A B Tobin, W Unger and N N Osborne (1988): Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. - J Neurosci, 8(10):3713-21.
  • R McCord, A Klein and N N Osborne (1996): The occurrence of protein kinase C theta and lambda isoforms in retina of different species. - Neurochem Res, 21(2):259-66.
  • J P Wood, G Pergande and N N Osborne (1998): Prevention of glutathione depletion-induced apoptosis in cultured human RPE cells by flupirtine. - Restor Neurol Neurosci, 12(2-3):119-25.
  • P J Boyd, N N Osborne and R J Walker (1987): Localization of ARG-vasopressin-like material in central neurones and mechanism of action of ARG-vasotocin on identified neurones of the snail Helix aspersa. - Neuropharmacology, 26(11):1633-47.
  • N N Osborne and A K Larsen (1996): Antigens associated with specific retinal cells are affected by ischaemia caused by raised intraocular pressure: effect of glutamate antagonists. - Neurochem Int, 29(3):263-70.
  • B Zhang and N N Osborne (2006): Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate. - Brain Res, 1124(1):176-87.
  • N N Osborne (1988): Tricyclic antidepressants, mianserin, and ouabain stimulate inositol phosphate formation in vitro in rat cortical slices. - Neurochem Res, 13(2):105-11.
  • N N Osborne (1982): Uptake, localization and release of serotonin in the chick retina. - J Physiol, 331:469-79.
  • N N Osborne, C Cazevieille, J P Wood, M S Nash, G Pergande, F Block, C Kosinski and M Schwarz (1998): Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. - Gen Pharmacol, 30(3):255-63.
  • N Nakamichi, G Chidlow and N N Osborne (2003): Effects of intraocular injection of a low concentration of zinc on the rat retina. - Neuropharmacology, 45(5):637-48.
  • G Chidlow, A Cupido, J Melena and N N Osborne (2001): Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits. - Curr Eye Res, 23(2):144-53.
  • N N Osborne and G Quack (1992): Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones. - Neurochem Int, 21(3):329-36.
  • N N Osborne (1990): Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rabbit retina. Evidence for a specific quisqualate receptor subtype associated with neurones. - Exp Eye Res, 50(4):397-405.
  • N N Osborne and A B Tobin (1987): Serotonin-accumulating cells in the iris-ciliary body and cornea of various species. - Exp Eye Res, 44(6):731-45.
  • C J Layton, R Safa and N N Osborne (2007): Oscillatory potentials and the b-Wave: partial masking and interdependence in dark adaptation and diabetes in the rat. - Graefes Arch Clin Exp Ophthalmol, 245(9):1335-45.
  • Neville N Osborne and John P M Wood (2006): The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis. - Invest Ophthalmol Vis Sci, 47(7):3178-86.
  • N N Osborne, R J McCord and J Wood (1995): The effect of kainate on protein kinase C, GABA, and the uptake of serotonin in the rabbit retina in vivo. - Neurochem Res, 20(6):635-41.
  • Bo Zhang, Rukhsana Safa, Dario Rusciano and Neville N Osborne (2007): Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion. - Brain Res, 1159:40-53.
  • U Meyer-Bothling, A J Bron and N N Osborne (1993): Topical application of serotonin or the 5-HT1-agonist 5-CT intraocular pressure in rabbits. - Invest Ophthalmol Vis Sci, 34(10):3035-42.
  • N N Osborne, S Patel, D W Beaton and V Neuhoff (1986): GABA neurones in retinas of different species and their postnatal development in situ and in culture in the rabbit retina. - Cell Tissue Res, 243(1):117-23.
  • Neville N Osborne and John P M Wood (2004): Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs. - Invest Ophthalmol Vis Sci, 45(10):3787-95.
  • H M Chao and N N Osborne (2001): Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. - Brain Res, 904(1):126-36.
  • N N Osborne, F Fitzgibbon, M Nash, N P Liu, R Leslie and A Cholewinski (1993): Serotonergic, 5-HT2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells. - Vision Res, 33(16):2171-9.
  • H Ghazi and N N Osborne (1989): Agonist-induced glycogenolysis in rabbit retinal slices and cultures. - Br J Pharmacol, 96(4):895-905.
  • Husnain Syed, Rukhsana Safa, Glyn Chidlow and Neville N Osborne (2006): Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide. - Neurochem Int, 48(8):708-17.
  • J Melena, D Stanton and N N Osborne (2001): Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels. - Graefes Arch Clin Exp Ophthalmol, 239(7):522-30.
  • Christopher J Layton, Simone Becker and Neville N Osborne (2006): The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2. - Mol Vis, 12:43-54.
  • M S Nash and N N Osborne (1999): Assessment of Thy-1 mRNA levels as an index of retinal ganglion cell damage. - Invest Ophthalmol Vis Sci, 40(6):1293-8.
  • N N Osborne and H Ghazi (1989): The effect of substance P and other tachykinins on inositol phospholipid hydrolysis in rabbit retina, superior colliculus and retinal cultures. - Vision Res, 29(7):757-64.
  • Kunizo Arai, John P M Wood and Neville N Osborne (2003): Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms. - Brain Res, 985(2):176-86.
  • Glyn Chidlow, Robert Casson, Paloma Sobrado-Calvo, Manuel Vidal-Sanz and Neville N Osborne (2005): Measurement of retinal injury in the rat after optic nerve transection: an RT-PCR study. - Mol Vis, 11:387-96.
  • Glyn Chidlow and Neville N Osborne (2003): Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light. - Brain Res, 963(1-2):298-306.
  • G Chidlow, L M De Santis, N A Sharif and N N Osborne (1995): Characteristics of [3H]5-hydroxytryptamine binding to iris-ciliary body tissue of the rabbit. - Invest Ophthalmol Vis Sci, 36(11):2238-45.
  • N N Osborne, N L Barnett and W Luttmann (1993): Endothelin receptors in the cornea, iris and ciliary processes. Evidence from binding, secondary messenger and PCR studies. - Exp Eye Res, 56(6):721-8.
  • N N Osborne, J P Wood, J Melena, H M Chao, M S Nash, A J Bron and G Chidlow (2000): 5-Hydroxytryptamine1A agonists: potential use in glaucoma. Evidence from animal studies. - Eye, 14 ( Pt 3B):454-63.
  • J P Wood, L DeSantis, H M Chao and N N Osborne (2001): Topically applied betaxolol attenuates ischaemia-induced effects to the rat retina and stimulates BDNF mRNA. - Exp Eye Res, 72(1):79-86.
  • N N Osborne, N L Barnett, N J Morris and F L Huang (1992): The occurrence of three isoenzymes of protein kinase C (alpha, beta and gamma) in retinas of different species. - Brain Res, 570(1-2):161-6.
  • G Chidlow, J Melena and N N Osborne (2000): Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists. - Br J Pharmacol, 130(4):759-66.
  • Neville N Osborne, Guang-Yu Li, Dan Ji, Heather J Mortiboys and Sandra Jackson (2008): Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies. - J Neurochem, 105(5):2013-28.
  • Belmira Lara da Silveira Andrade da Costa, Rebecca Fawcett, Guang-Yu Li, Rukhsana Safa and Neville N Osborne (2008): Orally administered epigallocatechin gallate attenuates light-induced photoreceptor damage. - Brain Res Bull, 76(4):412-23.
  • Robert J Casson, Glyn Chidlow, John P M Wood, Manuel Vidal-Sanz and Neville N Osborne (2004): The effect of retinal ganglion cell injury on light-induced photoreceptor degeneration. - Invest Ophthalmol Vis Sci, 45(2):685-93.
  • K J Buckett, G J Dockray, N N Osborne and P R Benjamin (1990): Pharmacology of the myogenic heart of the pond snail Lymnaea stagnalis. - J Neurophysiol, 63(6):1413-25.
  • J P Wood and N N Osborne (1997): Induction of apoptosis in cultured human retinal pigmented epithelial cells: the effect of protein kinase C activation and inhibition. - Neurochem Int, 31(2):261-73.
  • John P M Wood, Gerassimos Lascaratos, Anthony J Bron and Neville N Osborne (2008): The influence of visible light exposure on cultured RGC-5 cells. - Mol Vis, 14:334-44.
  • John P M Wood, Gerassimos Lascaratos, Anthony J Bron and Neville N Osborne (2007): The influence of visible light exposure on cultured RGC-5 cells. - Mol Vis, 14:334-44.
  • A Reichenbach, J Schnitzer, E Reichelt, N N Osborne, B Fritzsche, A Puls, U Richter, A Friedrich, A K Knothe and W Schober (1993): Development of the rabbit retina, III: Differential retinal growth, and density of projection neurons and interneurons. - Vis Neurosci, 10(3):479-98.
  • Ortrud Uckermann, Susann Uhlmann, Thomas Pannicke, Mike Francke, Ruslan Gamsalijew, Felix Makarov, Elke Ulbricht, Peter Wiedemann, Andreas Reichenbach, Neville N Osborne and Andreas Bringmann (2005): Ischemia-reperfusion causes exudative detachment of the rabbit retina. - Invest Ophthalmol Vis Sci, 46(7):2592-600.
  • Bo Zhang, Dario Rusciano and Neville N Osborne (2008): Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. - Brain Res, 1198:141-52.
  • J P Wood and N N Osborne (2001): The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells. - Arch Ophthalmol, 119(1):81-8.
  • G Chidlow, S Le Corre and N N Osborne (1998): Localization of 5-hydroxytryptamine1A and 5-hydroxytryptamine7 receptors in rabbit ocular and brain tissues. - Neuroscience, 87(3):675-89.
  • S H Jung, K D Kang, D Ji, R J Fawcett, R Safa, T A Kamalden and N N Osborne (2008): The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. - Neurochem Int, 53(6-8):325-37.
  • John P M Wood, Glyn Chidlow, Mark Graham and Neville N Osborne (2004): Energy substrate requirements of rat retinal pigmented epithelial cells in culture: relative importance of glucose, amino acids, and monocarboxylates. - Invest Ophthalmol Vis Sci, 45(4):1272-80.
  • Robert E MacLaren, Prateek K Buch, Alexander J Smith, Kamaljit S Balaggan, Angus MacNeil, Jeremy S Taylor, Neville N Osborne and Robin R Ali (2006): CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion. - Exp Eye Res, 83(5):1118-27.
  • N N Osborne, N J Broyden, N L Barnett and N J Morris (1991): Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments. - J Neurochem, 57(2):594-604.
  • R J Fawcett and N N Osborne (2007): Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ. - Brain Res Bull, 73(4-6):278-88.
  • Andreas Bringmann, Thomas Pannicke, Jens Grosche, Mike Francke, Peter Wiedemann, Serguei N Skatchkov, Neville N Osborne and Andreas Reichenbach (2006): Muller cells in the healthy and diseased retina. - Prog Retin Eye Res, 25(4):397-424.
  • J P M Wood, K-G Schmidt, J Melena, G Chidlow, H Allmeier and N N Osborne (2003): The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol. - Exp Eye Res, 76(4):505-16.
  • N N Osborne (1993): Neuromediators and their receptors (adrenergic and endothelin types) in the eye. - Therapie, 48(6):549-58.
  • N N Osborne, J Wood and A Muller (1995): The influence of experimental ischaemia on protein kinase C and the GABAergic system in the rabbit retina. - Neuropharmacology, 34(10):1279-88.
  • Neville N Osborne, John P M Wood, Alexander Cupido, Jose Melena and Glyn Chidlow (2002): Topical flunarizine reduces IOP and protects the retina against ischemia-excitotoxicity. - Invest Ophthalmol Vis Sci, 43(5):1456-64.
  • G Chidlow, M S Nash, L M De Santis and N N Osborne (1999): The 5-HT(1A)Receptor agonist 8-OH-DPAT lowers intraocular pressure in normotensive NZW rabbits. - Exp Eye Res, 69(6):587-93.
  • Neville N Osborne (2008): Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. - Prog Brain Res, 173:339-52.
  • L G Rodrigues, M A Tavares, J P M Wood, K-G Schmidt and N N Osborne (2004): Methamphetamine exacerbates the toxic effect of kainic acid in the adult rat retina. - Neurochem Int, 45(8):1133-41.
  • N N Osborne, C Cazevieille, G Pergande and J P Wood (1997): Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine. - Invest Ophthalmol Vis Sci, 38(7):1390-400.
  • M S Nash, J P Wood and N N Osborne (1997): Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells. - Exp Eye Res, 64(2):249-55.
  • N N Osborne, M Ugarte, M Chao, G Chidlow, J H Bae, J P Wood and M S Nash (1999): Neuroprotection in relation to retinal ischemia and relevance to glaucoma. - Surv Ophthalmol, 43 Suppl 1:S102-28.
  • J Melena and N N Osborne (2001): Voltage-dependent calcium channels in the rat retina: involvement in NMDA-stimulated influx of calcium. - Exp Eye Res, 72(4):393-401.
  • J P Wood, R J McCord and N N Osborne (1997): Retinal protein kinase C. - Neurochem Int, 30(2):119-36.
  • N N Osborne, A Larsen and N L Barnett (1995): Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. - Invest Ophthalmol Vis Sci, 36(8):1692-700.
  • A K Larsen and N N Osborne (1996): Involvement of adenosine in retinal ischemia. Studies on the rat. - Invest Ophthalmol Vis Sci, 37(13):2603-11.
  • N N Osborne, M S Nash and J P Wood (1998): Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells. - Invest Ophthalmol Vis Sci, 39(12):2374-83.
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